[1]李汉林,潘曈,仇雪梅,等.正常眼压性青光眼黄斑区视网膜厚度和血管密度变化及其与视野的相关性分析[J].眼科新进展,2020,40(11):1060-1064.[doi:10.13389/j.cnki.rao.2020.0237]
 LI Hanlin,PAN Tong,QIU Xuemei,et al.Changes in macular retinal thickness and macular vessel density in Normal-tension glaucoma and its correlation with visual field analysis[J].Recent Advances in Ophthalmology,2020,40(11):1060-1064.[doi:10.13389/j.cnki.rao.2020.0237]
点击复制

正常眼压性青光眼黄斑区视网膜厚度和血管密度变化及其与视野的相关性分析/HTML
分享到:

《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
40卷
期数:
2020年11期
页码:
1060-1064
栏目:
应用研究
出版日期:
2020-11-05

文章信息/Info

Title:
Changes in macular retinal thickness and macular vessel density in Normal-tension glaucoma and its correlation with visual field analysis
作者:
李汉林潘曈仇雪梅梁瀛彭志优周琼裴重刚
330006  江西省南昌市,南昌大学第一附属医院眼科
Author(s):
LI HanlinPAN TongQIU XuemeiLIANG YingPENG ZhiyouZHOU QiongPEI Chonggang
Department of Ophthalmology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China
关键词:
光学相干断层扫描血管成像正常眼压性青光眼黄斑区视野
Keywords:
optical coherence tomography angiography normal tension glaucoma macular area visual field
分类号:
R775
DOI:
10.13389/j.cnki.rao.2020.0237
文献标志码:
A
摘要:
目的 使用光学相干断层扫描血管成像(optical coherence tomography angiography,OCTA)观察正常眼压性青光眼(normal tension glaucoma,NTG)黄斑区视网膜厚度(macular retinal thickness,MRT)和黄斑区血管密度(macular vessel density,MVD)改变,并探讨其与视野平均缺损的相关性。方法 选取NTG 患者20例(40眼)为NTG组,健康20人(40眼)为对照组。利用OCTA检测2组MRT和MVD,对比NTG组与对照组间的差异性,并检验NTG组黄斑区检测指标与视野平均缺损的相关性。结果 NTG组与对照组受检者MRT、MVD在黄斑区中心凹、旁中心凹、上方及下方比较,差异均有统计学意义(F中心凹MRT=26.923、F旁中心凹MRT=38.176、F上方MRT=22.324、F下方MRT=39.936、F中心凹MVD=36.154、F旁中心凹MVD=45.573、F上方MVD=29.345、F下方MVD=30.267;均为P<0.01),而在颞侧和鼻侧两个象限MRT、MVD差异均无统计学意义(F颞侧MRT=2.614、F鼻侧MRT=2.497、F颞侧MVD=2.134、F鼻侧MVD=1.937;均为P>0.05);NTG组的黄斑中心凹、旁中心凹、上方及下方的MRT、MVD与视野平均缺损均具有相关性(均为P<0.01)。结论 利用OCTA技术可以有效地反映NTG黄斑区形态学改变特征,且这种改变与视野平均缺损相关,从而可在疾病的早期提供无创影像学诊断支持,为尽早干预治疗提供帮助。
Abstract:
Objective To use optical coherence tomography angiography (OCTA) to observe the changes of macular retinal thickness (MRT) and macular vessel density (MVD) in the macular area of normal-tension glaucoma ,and to explore its relevance to visual field.Methods Twenty NTG patients (40 eyes) were selected as the TNG group, and 20 patients (40 eyes) of normal persons as the control group. OCTA was used to obtain the MRT and MVD in the macular area. The difference between the NTG group and the control group was statistically analyzed and the correlation between the macular area detection index and the visual field defect in the NTG group was tested.Results We obtained the MRT and MVD in the macular area of the subject by OCTA, and found that there were statistically significant difference in the MRT and MVD in the macular area at the four directions of fovea, paracentral fovea, top and bottom between the NTG group and the control group(Ffovea MRT=26.923,Fparacentral fovea MRT=38.176,Ftop MRT=22.324,Fbottom MRT=39.936,Ffovea MVD=36.154,Fparacentral MVD=45.573,Ftop MVD=29.345,Fbottom MVD=30.267;All P<0.01), but there was no statistical difference between two groups in temporal and nasal sides (Ftemporal MRT=2.614,Fnasal MRT=2.497,Ftemporal MVD=2.134,Fnasal MVD=1.937;All P>0.05). The fovea, paracentral fovea, top and bottom of the NTG group were correlated with the mean deviation of visual field (all P<0.01).Conclusion The use of OCTA technology can effectively reflect the characteristics of NTG macular morphological changes, and this change is related to visual field defect, which can provide non-invasive imaging diagnosis support in the early stage of the disease and provide help for early intervention treatment.

参考文献/References:

[1] ZHAO J,SOLANO M M,OLDENBURG C E,LIU T,WANG Y,WANG N,et al.Prevalence of normal-tension glaucoma in the Chinese population:a systematic review and meta analysis[J].Am J Ophthalmol,2019,199(3):101-110.
[2] WEINREB R N,AUNG T,MEDEIROS F A.The pathophysiology and treatment of glaucoma:a review[J].JAMA,2014,311:1901-1911.
[3] FLAMMER J,MOZAFFARIEH M.What is the present pathogenetic concept of glaucomatous optic neuropathy?[J].Surv Ophthalmol,2007,52(Suppl 6):S162-173.
[4] SUH M H,ZANGWILL L M,MANALASTAS P I,BELGHITH A,YARMOHAMMADI A,MEDEIROS F A,et al.Optical coherence tomography angiography vessel density in glaucomatous eyes with focal lamina cribrosa defects[J].Ophthalmology,2016,123(11):2309-2317.
[5] RAO H L,PRADHAN Z S,WEINREB R N,REDDY H B,RIYAZUDDIN M,SACHDEVA S,et al.Determinants of peripapillary and macular vessel densities measured by optical coherence tomography angiography in normal eyes[J].J Glaucoma,2017,26(5):491-497.
[6] KWON J,CHOI J,SHIN J W,LEE J,KOOK M S.Alterations of the foveal avascular zone measured by optical coherence tomography angiography in glaucoma patients with central visual field defects[J].Invest Ophthalmol Vis Sci,2017,58(3):1637-1645.
[7] 郭冉阳.光学相干断层扫描仪对原发性开角型青光眼患者早期诊断价值[J].新乡医学院学报,2016,33(8):723-726.
GUO R Y .Value of optical coherence tomography in the early diagnosis of primary open angle glaucoma[J].J Xinxiang Med Univ,2016,33(8):723-726.
[8] DASCLU A M,ALEXANDRESCU C,POPA-CHERECHEANU A,STANA D,PANCA A,PASCU R,et al.Structure-function correlation in early diagnosis of glaucoma progression[J].Oftalmologia,2011,55(4):111-116.
[9] MAPSTONE R.Acute shallowing of the anterior chamber[J].Br J Ophthalmol,1981,65:446-451.
[10] WISHART P K.Can the pilocarpine phenylephrine provocative test be used to detect covert angle closure?[J].Br J Ophthalmol,1991,75:615-618.
[11] WEINREB R N,KHAW P T.Primary open-angle glaucoma[J].Lancet,2004,363(9422):1711-1720.
[12] REN R,WANG N L,ZHANG X J,CUI T T,JONAS J B.Trans-lamina cribrosa pressure difference correlated with neuroretinal rim area in glaucoma[J].Graefes Arch Clin Exp Ophthalmol,2011,249(7):1057-1063.
[13] HOU R,ZHANG Z,YANG D,WANG H,CHEN W,LI Z,et al.Pressure balance and imbalance in the optic nerve chamber:the Beijing intracranial and intraocular pressure(iCOP) study[J].Sci China Life Sci,2016,59(5):495-503.
[14] ZHANG Z,LIU D,JONAS J B,SHEN W,KWONG M K,JINGXUE Z,et al.Axonal transport in the rat optic nerve following short term reduction in cerebrospinal fluid pressure or elevation in intraocular pressure[J].Invest Ophthalmol Vis Sci,2015,56(8):4257-4266.
[15] 于静,王怀洲,王宁利,邱礼新.阴虚体质正常眼压性青光眼中医药治疗初探[J].中国中医眼科杂志,2018,28(4):250-254.
YU J,WANG H Z,WANG N L,QIU L X.Traditional Chinese medical treatment for normal tension glaucoma cases with Yin deficiency constitution[J].CHN J Chin Ophthalmol,2018,28(4):250-254.
[16] DIYA Y,JIDI F,RUOWU H,KEGAO L,JONAS J B,HUAIZHOU W,et al.Optic neuropathy induced by experimentally reduced cerebrospinal fluid pressure in monkeys[J].Invest Ophthalmol Vis Sci,2014,55(5):3067-3073.

相似文献/References:

[1]丁琼 谭荣强 郑春昌 郑诚.药物干预对早期正常眼压性青光眼预后的影响[J].眼科新进展,2012,32(12):000.
[2]王莎莎 汪昌运.正常眼压性青光眼的研究进展[J].眼科新进展,2013,33(10):000.
[3]叶计芬 杨艳芳 赵青. 高眼压性和正常眼压性青光眼P-VEP与视野缺损的相关性研究[J].眼科新进展,2014,34(3):248.
[4]吴文文,唐莉. 低颅压与正常眼压性青光眼的关系[J].眼科新进展,2015,35(4):390.[doi:10.13389/j.cnki.rao.2015.0106]
 WU Wen-Wen,TANG Li. Correlation between low intracranial pressure and normal-tension glaucoma[J].Recent Advances in Ophthalmology,2015,35(11):390.[doi:10.13389/j.cnki.rao.2015.0106]
[5]李汉林,邵毅,彭志优,等.正常眼压性青光眼的rsfMRI-fALFF研究及其与OCT及视野相关性分析[J].眼科新进展,2016,36(1):056.[doi:10.13389/j.cnki.rao.2016.0016]
 LI Han-Lin,SHAO Yi,PENG Zhi-You,et al.Study and correlative amdysis between rsfMRI-fALFF and OCT ,visual field in normal tension glaucoma[J].Recent Advances in Ophthalmology,2016,36(11):056.[doi:10.13389/j.cnki.rao.2016.0016]
[6]董秀芬,钟华.Angio-OCT在眼科疾病临床应用中研究进展[J].眼科新进展,2016,36(7):697.[doi:10.13389/j.cnki.rao.2016.0185]
 DONG Xiu-Fen,ZHONG Hua.Application of Angio-OCT in ophthalmic diseases[J].Recent Advances in Ophthalmology,2016,36(11):697.[doi:10.13389/j.cnki.rao.2016.0185]
[7]李汉林,邵毅,彭志优,等.正常眼压性青光眼磁共振扩散张量成像技术(DTI)研究及其与临床分期的相关性[J].眼科新进展,2016,36(12):1129.[doi:10.13389/j.cnki.rao.2016.0301]
 LI Han-Lin,SHAO Yi,PENG Zhi-You,et al.Study and correlative analysis between DTI parameters and clinical stages in normal tension glaucoma[J].Recent Advances in Ophthalmology,2016,36(11):1129.[doi:10.13389/j.cnki.rao.2016.0301]
[8]刘青,艾明.光学相干断层扫描血管成像(OCTA)和荧光素血管造影(FFA)对比观察增生型糖尿病视网膜病变(PDR)[J].眼科新进展,2017,37(1):052.[doi:10.13389/j.cnki.rao.2017.0014]
 LIU Qing,AI Ming.Characteristics of proliferative diabetic retinopathy observed by optical coherence tomography angiography and fundus fluorescein angiography[J].Recent Advances in Ophthalmology,2017,37(11):052.[doi:10.13389/j.cnki.rao.2017.0014]
[9]仲妍,车慧欣.光学相干断层扫描血管成像(OCTA)在原发性青光眼患者中的检测价值[J].眼科新进展,2018,38(4):352.[doi:10.13389/j.cnki.rao.2018.0082]
 ZHONG Yan,CHE Hui-Xin.Detective values of optical coherence tomography angiographyfor primary glaucoma[J].Recent Advances in Ophthalmology,2018,38(11):352.[doi:10.13389/j.cnki.rao.2018.0082]
[10]冷云霞,张柳,张蒙,等.早产儿视网膜病变黄斑中心视网膜微血管形态特征:基于光学相干断层扫描血管成像(OCTA)的观察[J].眼科新进展,2018,38(4):357.[doi:10.13389/j.cnki.rao.2018.0083]
 LENG Yun-Xia,ZHANG Liu,ZHANG Meng,et al.Observation of central macular retinal microvascular network morphology of retinopathy of prematurity by optical coherence tomography angiography[J].Recent Advances in Ophthalmology,2018,38(11):357.[doi:10.13389/j.cnki.rao.2018.0083]

备注/Memo

备注/Memo:
江西省重点研发计划项目(编号:20202BBGL73019、20171BBG70097);江西省科技支撑计划项目(编号:20161BBG70164);江西省教育厅科技计划项目(编号:GJJ150242);江西省卫计委科技计划项目(编号:20181032、20155131) ;江西省学位与研究生教育教学改革项目(编号:JXYJG-2019-029)
更新日期/Last Update: 2020-11-05